Short descriptions and photographs of some photogenic microorganisms. Recent revisions indicate that F. DNA analysis, however, has added a second species to the genus known as F. There are subtle morphological differences between the two; however, they are best differentiated by molecular means. The fungal disease was first described by Alexandrino Pedroso in , hence the name. Ecology: While Fonsecaea can be found worldwide it is more commonly found in tropical and sub-tropical regions where it is found as a saprobe lives on dead organic matter in soils and rotting plant materials.
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Corresponding author. Corresponding author: Moo Kyu Suh, M. Tel: , Fax: , rk. This article has been cited by other articles in PMC. Abstract We report herein a case of chromoblastomycosis caused by Fonsecaea F. Histopathologically, chronic granulomatous inflammation and either sclerotic or muriform cells were observed. The fungal culture produced typical black colonies of F.
The patient was treated with mg of itraconazole daily, for 3 months. Skin lesions were improved. In Korea, only 9 cases of chromoblastomycosis, including this case, have been reported until now. The etiologic agent was F. The incidence of chromoblastomycosis was slightly higher in female, and the upper limbs were more affected than the lower limbs in patients.
This disease is mostly reported in tropical and subtropical areas and is often caused by Fonsecaea F. Other lesser etiologic agents are Cladosporium Cladophialophora carrionii, Phialophora verrucosa, Rhinocladiella aquaspersa, F. This rare skin disease, caused by fungus profundus, is rarely reported in Korea, compared to Japan 4 - 7 , even though these two countries are in the same Northeast Asia region.
In Korea, clinical and histological findings have led to diagnosis of this disease by Ahn and Lee 8 in Since the first identification of the etiologic agent by Suh et al. Therefore, we present herein the case of a year-old male patient who developed multiple erythematous plaques on the left lower leg. Clinical and histopathological findings, as well as fungus culture, light microscope findings and molecular biological analysis, have led us to diagnose the patient with chromoblastomycosis, caused by F.
The findings were presented with a review of the literature and previous reports of chromoblastomycosis in Korea. He was a Thai worker living in Korea, and without specific traumatic event, he had the asymptomatic eythematous papule for 12 months. The patient had history of visiting Thailand 15 months ago. The lesion gradually increased in size and eventually developed into ulcerative erythematous plaque.
His past medical history and family history was unremarkable. On physical examination, the general physical condition was good and there were no specific findings, except for the skin lesion. On the visit, laboratory studies, including complete blood cell count with differentials, peripheral blood smear, liver and renal function test, VDRL, urinalysis, stool examination, hepatitis viral test, HIV test, chest X-ray, and electrocardiogram were all within normal limits or negative.
KOH mount did not result in finding of any etiological agent. Same result was found with subculture on plate medium Fig. According to microscopic examination with Lactophenol cotton blue staining for hyphae and conidia, conidiophores were brown, and ovoid conidia were located either at end or at the side of conidiophores Fig.
Histopathological examination revealed chronic granulomatous inflammation, with phase disseminated hyperplastic, minute abscess and intradermal lymphocytes, histiocytes, and giant cells Fig. Also, large spherical thick walled cells formed a cluster Fig. Subsequently, using the Blast program, it was compared to the base sequence of the reported strain in Thailand stored in GeneBank , i. With clinical, histopathological and mycological results, as well as molecular biological findings, we were able to diagnose the patient as having chromoblastomycosis caused by the strain F.
The patient showed clinical improvement to 3 months oral administration of itraconazole, mg per day.
The primary conidia function as sympodial conidiogenous cells to form the secondary conidia Muriform cells Medlar bodies from a case of chromoblastomycosis Description and Natural Habitats Fonsecaea is a pigmented dematiaceous , filamentous fungus found in rotten wood and soil. It has no known teleomorphic phase. As well as being a saprophyte in nature, it causes infections in humans. Cold-blooded animals living in swamps may also be infected. Fonsecaea exhibits in vivo dimorphism; it produces a specific structure sclerotic body only in tissue and grows in mould form in laboratory conditions [ , , , , ]. Species The genus Fonsecaea contains two species: Fonsecaea compacta and Fonsecaea pedrosoi.